Sort by: Faculty Programs Years Advanced

Accomplishments by Gilbert M Rishton

2006

Exhibitions / Presentations:

  • "Novel and Leadlike Alkaloidal Beta-Secretase Inhibitors Derived from Ginger Oil by Conditioned Extraction." Paper delivered at Drug Discovery Chemistry. La Jolla, CA, Apr 25, 2006. Natural Products Chemistry Cambridge Healthtech Institute. (http://www.chiresource.com/LDS-pdf-5-26/Presentations_NAT.asp)
  • "Chemically Conditioned Extracts of Ginger Oil: Leadlike Alkaloidal Compounds Derived from Natural Extracts via Reductive Amination." with H. Arai, K. Beierle, C. Fullenwider, and Z. Kai. Paper delivered at American Chemical Society Western Regional Meeting. Anaheim, CA, Jan 22, 2006. (http://acs.confex.com/acs/werm05/techprogram/S2455.HTM)
  • "Chemically Conditioned Extracts of Ginger Oil: Leadlike Alkaloidal Compounds Derived from Natural Extracts via Reductive Amination." with H. Arai, K. Beierle, C. Fullenwider, and Z. Kai. Paper delivered at 18 th Annual CSU Biotechnology Symposium. San Jose, CA, Jan 13, 2006. The Brain and the Future (http://www.csuchico.edu/csuperb/Sym06_Program.pdf)
  • "Chemically Conditioned Extracts of Ginger Oil: Leadlike Compounds Derived from Natural Extracts for Biochemical Screening." with H. Arai and Z. Kai. Paper delivered at Biomedical Research Conference for Minority Students. Atlanta, GA, Nov 2, 2005. (http://www.abrcms.org/page01a.html)
  • "Evaluation of p38a inhibitors with improved metabolic stability." with et al. Paper delivered at 230th ACS National Meeting. Washington, D.C., Aug 28, 2005. Medicinal Chemistry (http://www.chemistry.org/portal/a/c/s/1/acsdisplay.html?DOC=meetings%5Cwashington2005%5Chome.html)
  • "Nonleadlikeness, Leadlikeness, and Target Tractability in Small Molecule Drug Discovery." Paper delivered at Molecules that Matter. Berlin, Germany, Apr 12, 2005. Case Studies in Medicinal Chemistry

Publications:

  • "The NIH Roadmap Initiative: Small Molecules, Big Opportunities." SoCalBio Synergies. Vol. 2 No. 4 Summer 2006 Jul 15, 2006. 1-3. (http://www.socalbio.org/newsletter/summer2006/summer2006.pdf)
  • "Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer's disease." with K. LaBonte, A. Williams, K. Kassam, and E. Kolovonov. Current Opinion in Drug Discovery & Drug Development. Vol. 9 No. 3 2006. 303-313. (http://scientific.thomson.com/media/cdjournals/codddpdf/vol9/coddd9-3.pdf)
  • "Medicinal Chemistry Equals New Leads." with S. Aldridge. Genetic Engineering News. Vol. 25 No. 10 May 15, 2005. 1. (http://www.genengnews.com/articles/chitem.aspx?aid=977&chid=1)
  • "Failure and Success in Modern Drug Discovery: Guiding Principles in the Establishment of High Probability of Success Drug Discovery Organizations." Medicinal Chemistry. Vol. 1 No. 5 2005. 519-527.
  • "Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl." with et al. Experimental Therapeutics. Vol. 308 No. 2 2004. 627-635.

Other Activities:

  • UNNATURAL BETA-SECRETASE INHIBITORS DERIVED FROM CONDITIONED EXTRACTION OF GINGER ROOT. with H. Arai, Z. Kai, C. Fullenwider, and K. Beierle. Provisional patent application. Sheldon & Mak, Pasadena. Oct 30, 2006.
  • Substituted pyridine and pyrimidine compounds as pharmaceutical agents, their preparation, pharmaceutical compositions, and use in therapy. with et al. US Patent Application: U.S. Pat. Appl. Publ. (2006), 86 pp. CODEN: USXXCO US 2006069110 A1 20060330 CAN 144:350705 AN 2006:293263. USA. 2006.